Schematics and AFM images of ATP receptor	Conformational changes in ATP receptor

　

Observation of Ligand-Induced Conformational Changes in Single ATP Receptors with Fast-Scanning Atomic Force Microscopy

　

Proteins, known as "receptors" that exist in cells, exhibit their functions via binding with small compounds such as hormones. When the receptor is a type of ion channel, it opens its pore after binding with compounds thereby flowing ions through it and resulting in exhibiting its function. We observed the topology and stimulation-induced conformational changes in adenosine triphosphate (ATP) receptor, an important receptor in pain sensation, with atomic force microscopy (AFM). (Page 20)

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